Equal randomization: several treatments more effective in distinctive signatures (cfr scen 7)
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| — | param | scale = 0.024, shape = 1.3 | scale = 0.014, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 66.5, median = 54.4 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | |
| effect | af = 1, hr = 1 | af = 1.7, hr = 0.5 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | |
| –+ | param | scale = 0.024, shape = 1.3 | scale = 0.014, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.029, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 66.5, median = 54.4 | mean = 70.5, median = 57.5 | mean = 31.9, median = 26.1 | |
| effect | af = 1, hr = 1 | af = 1.7, hr = 0.5 | af = 1.8, hr = 0.46 | af = 0.82, hr = 1.3 | |
| -+- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | |
| -++ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.029, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 31.9, median = 26.1 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 0.82, hr = 1.3 | |
| +– | param | scale = 0.024, shape = 1.3 | scale = 0.014, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 66.5, median = 54.4 | mean = 31.9, median = 26.1 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 1.7, hr = 0.5 | af = 0.82, hr = 1.3 | af = 1.9, hr = 0.43 | |
| +-+ | param | scale = 0.024, shape = 1.3 | scale = 0.014, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 66.5, median = 54.4 | mean = 70.5, median = 57.5 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 1.7, hr = 0.5 | af = 1.8, hr = 0.46 | af = 1.9, hr = 0.43 | |
| ++- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 31.9, median = 26.1 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.82, hr = 1.3 | af = 1.9, hr = 0.43 | |
| +++ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 1.9, hr = 0.43 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| all | param | scale = 0.024, shape = 1.3 | scale = 0.022, shape = 1.3 | scale = 0.021, shape = 1.3 | scale = 0.021, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 42.3, median = 34.6 | mean = 43, median = 35.1 | mean = 43.6, median = 35.6 | |
| effect | af = 1, hr = 1 | af = 1.08, hr = 0.9 | af = 1.1, hr = 0.88 | af = 1.12, hr = 0.87 | |
| TP53- | param | scale = 0.024, shape = 1.3 | scale = 0.014, shape = 1.3 | scale = 0.021, shape = 1.3 | scale = 0.021, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 66.5, median = 54.4 | mean = 43, median = 35.1 | mean = 43.6, median = 35.6 | |
| effect | af = 1, hr = 1 | af = 1.7, hr = 0.5 | af = 1.1, hr = 0.88 | af = 1.12, hr = 0.87 | |
| TP53+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.021, shape = 1.3 | scale = 0.021, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 43, median = 35.1 | mean = 43.6, median = 35.6 | |
| effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.1, hr = 0.88 | af = 1.12, hr = 0.87 | |
| DRD+ | param | scale = 0.024, shape = 1.3 | scale = 0.022, shape = 1.3 | scale = 0.021, shape = 1.3 | scale = 0.012, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 42.3, median = 34.6 | mean = 43, median = 35.1 | mean = 74.3, median = 60.7 | |
| effect | af = 1, hr = 1 | af = 1.08, hr = 0.9 | af = 1.1, hr = 0.88 | af = 1.9, hr = 0.43 | |
| TEfus+ | param | scale = 0.024, shape = 1.3 | scale = 0.022, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.021, shape = 1.3 |
| summary | mean = 39, median = 31.9 | mean = 42.3, median = 34.6 | mean = 70.5, median = 57.5 | mean = 43.6, median = 35.6 | |
| effect | af = 1, hr = 1 | af = 1.08, hr = 0.9 | af = 1.8, hr = 0.46 | af = 1.12, hr = 0.87 |
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The overall error was 0.09.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Niraparib
0.016 0.058 0.016
The overall power was 0.878.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Niraparib
0.408 0.484 0.604
| signature | var | Control | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| all | graduation | 0 | 15 | 8 | 3 |
| futility | 0 | 5 | 5 | 5 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 539 (474, 594) | 338 (188, 468) | 412 (265, 538) | 441 (276, 541) | |
| n_unique | 539 (474, 594) | 338 (188, 468) | 412 (265, 538) | 441 (276, 541) | |
| time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | |
| time_stop | NA (NA, NA) | 14 (9, 26) | 15 (8, 31) | 16 (10, 18) | |
| post_p | NA (NA, NA) | 0.95 (0.52, 1) | 0.39 (0.05, 0.81) | 0.13 (0.01, 0.53) | |
| rate | 0.019 (0.018, 0.021) | 0.017 (0.014, 0.019) | 0.02 (0.018, 0.022) | 0.021 (0.02, 0.024) | |
| TP53- | graduation | 0 | 204 | 4 | 3 |
| futility | 0 | 13 | 158 | 124 | |
| max_n | 0 | 67 | 62 | 79 | |
| n | 290 (249, 328) | 223 (87, 301) | 236 (71, 300) | 240 (68, 302) | |
| n_unique | 290 (249, 328) | 223 (87, 301) | 236 (71, 300) | 240 (68, 302) | |
| time_trial | 60 (60, 60) | 60 (25, 60) | 60 (17, 60) | 60 (17, 60) | |
| time_stop | NA (NA, NA) | 37 (16, 55) | 22 (12, 41) | 18 (13, 36) | |
| post_p | NA (NA, NA) | 1 (0.95, 1) | 0.07 (0, 0.39) | 0.06 (0, 0.32) | |
| rate | 0.017 (0.015, 0.019) | 0.011 (0.009, 0.013) | 0.021 (0.018, 0.025) | 0.021 (0.019, 0.025) | |
| TP53+ | graduation | 0 | 0 | 54 | 17 |
| futility | 0 | 362 | 28 | 35 | |
| max_n | 0 | 2 | 17 | 18 | |
| n | 249 (206, 287) | 103 (53, 216) | 209 (81, 267) | 216 (118, 269) | |
| n_unique | 249 (206, 287) | 103 (53, 216) | 209 (81, 267) | 216 (118, 269) | |
| time_trial | 60 (60, 60) | 34 (17, 60) | 60 (31, 60) | 60 (49, 60) | |
| time_stop | NA (NA, NA) | 25 (16, 46) | 24 (16, 50) | 21 (14, 34) | |
| post_p | NA (NA, NA) | 0.07 (0, 0.4) | 0.89 (0.46, 0.99) | 0.59 (0.16, 0.92) | |
| rate | 0.022 (0.019, 0.024) | 0.028 (0.024, 0.034) | 0.019 (0.016, 0.022) | 0.022 (0.019, 0.025) | |
| DRD+ | graduation | 0 | 9 | 4 | 302 |
| futility | 0 | 68 | 64 | 0 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 148 (119, 175) | 91 (50, 133) | 111 (57, 156) | 91 (53, 152) | |
| n_unique | 148 (119, 175) | 91 (50, 133) | 111 (57, 156) | 91 (53, 152) | |
| time_trial | 60 (60, 60) | 60 (35, 60) | 60 (40, 60) | 53 (29, 60) | |
| time_stop | NA (NA, NA) | 30 (23, 51) | 30 (22, 46) | 41 (26, 56) | |
| post_p | NA (NA, NA) | 0.71 (0.21, 0.96) | 0.51 (0.11, 0.91) | 1 (0.95, 1) | |
| rate | 0.018 (0.015, 0.021) | 0.016 (0.013, 0.021) | 0.018 (0.015, 0.022) | 0.01 (0.008, 0.012) | |
| TEfus+ | graduation | 0 | 1 | 242 | 0 |
| futility | 0 | 176 | 3 | 107 | |
| max_n | 0 | 0 | 0 | 0 | |
| n | 203 (164, 234) | 104 (51, 176) | 136 (64, 207) | 159 (59, 215) | |
| n_unique | 203 (164, 234) | 104 (51, 176) | 136 (64, 207) | 159 (59, 215) | |
| time_trial | 60 (60, 60) | 60 (21, 60) | 60 (27, 60) | 60 (24, 60) | |
| time_stop | NA (NA, NA) | 28 (18, 53) | 37 (24, 55) | 25 (18, 38) | |
| post_p | NA (NA, NA) | 0.28 (0.03, 0.8) | 0.99 (0.89, 1) | 0.11 (0.01, 0.52) | |
| rate | 0.016 (0.014, 0.019) | 0.018 (0.015, 0.023) | 0.01 (0.009, 0.013) | 0.02 (0.017, 0.024) |
| subtype | var | Control | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|---|
| — | graduation | 0 | 226 | 171 | 132 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 67 | 62 | 79 | |
| n | 156 (127, 190) | 130 (46, 171) | 134 (39, 171) | 139 (37, 178) | |
| n_unique | 156 (127, 190) | 130 (46, 171) | 134 (39, 171) | 139 (37, 178) | |
| post_p | NA (NA, NA) | 1 (0.92, 1) | 0.02 (0, 0.23) | 0.02 (0, 0.19) | |
| rate | 0.019 (0.016, 0.022) | 0.011 (0.009, 0.014) | 0.027 (0.023, 0.032) | 0.027 (0.023, 0.031) | |
| –+ | graduation | 0 | 361 | 337 | 193 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 64 | 57 | 78 | |
| n | 49 (33, 63) | 29 (11, 53) | 29 (11, 52) | 40 (11, 61) | |
| n_unique | 49 (33, 63) | 29 (11, 53) | 29 (11, 52) | 40 (11, 61) | |
| post_p | NA (NA, NA) | 0.72 (0.31, 0.94) | 0.78 (0.39, 0.97) | 0.02 (0, 0.18) | |
| rate | 0.013 (0.009, 0.018) | 0.012 (0.007, 0.017) | 0.01 (0.006, 0.016) | 0.027 (0.02, 0.037) | |
| -+- | graduation | 0 | 378 | 91 | 56 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 17 | 18 | |
| n | 101 (82, 127) | 46 (22, 95) | 95 (39, 119) | 96 (51, 118) | |
| n_unique | 101 (82, 127) | 46 (22, 95) | 95 (39, 119) | 96 (51, 118) | |
| post_p | NA (NA, NA) | 0.39 (0.08, 0.79) | 0.35 (0.06, 0.8) | 0.39 (0.06, 0.8) | |
| rate | 0.025 (0.021, 0.029) | 0.028 (0.023, 0.035) | 0.027 (0.023, 0.033) | 0.027 (0.022, 0.032) | |
| -++ | graduation | 0 | 426 | 294 | 143 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 16 | 18 | |
| n | 81 (57, 102) | 28 (15, 69) | 61 (22, 89) | 73 (21, 100) | |
| n_unique | 81 (57, 102) | 28 (15, 69) | 61 (22, 89) | 73 (21, 100) | |
| post_p | NA (NA, NA) | 0.09 (0, 0.41) | 0.98 (0.81, 1) | 0.07 (0, 0.38) | |
| rate | 0.019 (0.015, 0.023) | 0.029 (0.022, 0.038) | 0.011 (0.007, 0.015) | 0.027 (0.021, 0.034) | |
| +– | graduation | 0 | 285 | 210 | 345 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 65 | 62 | 67 | |
| n | 42 (30, 55) | 32 (11, 49) | 34 (10, 51) | 26 (10, 46) | |
| n_unique | 42 (30, 55) | 32 (11, 49) | 34 (10, 51) | 26 (10, 46) | |
| post_p | NA (NA, NA) | 0.87 (0.56, 0.99) | 0.09 (0.01, 0.42) | 0.92 (0.67, 0.99) | |
| rate | 0.018 (0.014, 0.025) | 0.011 (0.007, 0.017) | 0.027 (0.02, 0.038) | 0.01 (0.006, 0.015) | |
| +-+ | graduation | 0 | 384 | 370 | 385 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 62 | 57 | 66 | |
| n | 41 (25, 55) | 24 (9, 49) | 24 (9, 47) | 22 (9, 45) | |
| n_unique | 41 (25, 55) | 24 (9, 49) | 24 (9, 47) | 22 (9, 45) | |
| post_p | NA (NA, NA) | 0.63 (0.23, 0.91) | 0.67 (0.27, 0.93) | 0.69 (0.35, 0.93) | |
| rate | 0.013 (0.009, 0.019) | 0.011 (0.007, 0.017) | 0.01 (0.006, 0.017) | 0.01 (0.006, 0.015) | |
| ++- | graduation | 0 | 396 | 149 | 325 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 17 | 15 | |
| n | 33 (23, 43) | 13 (6, 32) | 30 (9, 42) | 24 (10, 37) | |
| n_unique | 33 (23, 43) | 13 (6, 32) | 30 (9, 42) | 24 (10, 37) | |
| post_p | NA (NA, NA) | 0.35 (0.07, 0.77) | 0.36 (0.07, 0.78) | 0.98 (0.84, 1) | |
| rate | 0.025 (0.018, 0.033) | 0.029 (0.019, 0.044) | 0.027 (0.019, 0.037) | 0.01 (0.005, 0.015) | |
| +++ | graduation | 0 | 436 | 342 | 386 |
| futility | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 16 | 15 | |
| n | 31 (17, 45) | 12 (6, 32) | 22 (9, 40) | 20 (8, 39) | |
| n_unique | 31 (17, 45) | 12 (6, 32) | 22 (9, 40) | 20 (8, 39) | |
| post_p | NA (NA, NA) | 0.17 (0.02, 0.52) | 0.89 (0.53, 0.99) | 0.88 (0.53, 0.99) | |
| rate | 0.019 (0.013, 0.026) | 0.028 (0.019, 0.045) | 0.01 (0.005, 0.016) | 0.01 (0.006, 0.018) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|
| all | count | 15 | 8 | 3 |
| time_stop | 13 (9, 25) | 22 (11, 30) | 13 (11, 17) | |
| n_trt | 100 (69, 200) | 150 (71, 228) | 106 (77, 123) | |
| n_control | 87 (72, 181) | 181 (82, 256) | 103 (89, 141) | |
| post_p | 0.98 (0.91, 1) | 0.98 (0.95, 1) | 0.96 (0.95, 0.97) | |
| order | 1 (1, 2.6) | 1.5 (1, 3.3) | 1 (1, 1) | |
| TP53- | count | 204 | 4 | 3 |
| time_stop | 38 (17, 55) | 25 (13, 42) | 17 (15, 22) | |
| n_trt | 164 (63, 257) | 106 (60, 173) | 69 (61, 101) | |
| n_control | 168 (71, 273) | 116 (55, 182) | 73 (67, 100) | |
| post_p | 1 (0.95, 1) | 0.96 (0.94, 0.98) | 0.98 (0.95, 0.98) | |
| order | 1 (1, 3) | 1.5 (1, 3.4) | 1 (1, 2.6) | |
| TP53+ | count | 54 | 17 | |
| time_stop | 32 (18, 52) | 23 (15, 46) | ||
| n_trt | 100 (61, 191) | 71 (54, 179) | ||
| n_control | 113 (56, 210) | 75 (47, 150) | ||
| post_p | 0.97 (0.92, 1) | 0.98 (0.93, 1) | ||
| order | 1 (1, 2.7) | 1 (1, 2) | ||
| DRD+ | count | 9 | 4 | 302 |
| time_stop | 49 (26, 59) | 46 (30, 56) | 41 (26, 56) | |
| n_trt | 63 (51, 121) | 68 (55, 124) | 82 (52, 138) | |
| n_control | 125 (62, 176) | 114 (66, 155) | 101 (59, 148) | |
| post_p | 0.98 (0.94, 0.99) | 0.99 (0.98, 0.99) | 0.99 (0.97, 1) | |
| order | 3 (1.8, 4) | 1.5 (1, 2.7) | 2 (1, 3) | |
| TEfus+ | count | 1 | 242 | |
| time_stop | 21 (21, 21) | 37 (24, 55) | ||
| n_trt | 55 (55, 55) | 108 (59, 187) | ||
| n_control | 63 (63, 63) | 125 (66, 194) | ||
| post_p | 0.95 (0.95, 0.95) | 0.99 (0.94, 1) | ||
| order | 2 (2, 2) | 1 (1, 3) |
| signature | var | Hormone_therapies | Taxel_therapies | Niraparib |
|---|---|---|---|---|
| all | count | 5 | 5 | 5 |
| time_stop | 18 (11, 29) | 13 (9, 35) | 16 (12, 18) | |
| n_trt | 122 (78, 180) | 93 (69, 174) | 117 (92, 126) | |
| n_control | 125 (76, 242) | 96 (68, 289) | 113 (92, 146) | |
| post_p | 0.09 (0.04, 0.17) | 0.05 (0.02, 0.11) | 0.02 (0, 0.1) | |
| order | 3 (1.4, 3.6) | 1 (1, 2.8) | 2 (1, 4) | |
| TP53- | count | 13 | 158 | 124 |
| time_stop | 15 (11, 29) | 22 (13, 40) | 18 (13, 37) | |
| n_trt | 58 (52, 93) | 94 (55, 174) | 79 (52, 150) | |
| n_control | 69 (42, 135) | 92 (52, 183) | 81 (49, 162) | |
| post_p | 0.18 (0.11, 0.26) | 0.08 (0.01, 0.26) | 0.1 (0.02, 0.22) | |
| order | 1 (1, 2.8) | 2 (1, 3) | 1 (1, 3) | |
| TP53+ | count | 362 | 28 | 35 |
| time_stop | 25 (16, 46) | 18 (15, 33) | 19 (14, 30) | |
| n_trt | 82 (53, 164) | 64 (52, 125) | 71 (52, 96) | |
| n_control | 86 (52, 183) | 64 (50, 133) | 68 (46, 107) | |
| post_p | 0.12 (0.02, 0.24) | 0.15 (0.11, 0.23) | 0.1 (0.02, 0.26) | |
| order | 2 (1, 3) | 2 (1, 3) | 1 (1, 3) | |
| DRD+ | count | 68 | 64 | |
| time_stop | 28 (23, 44) | 30 (22, 46) | ||
| n_trt | 58 (50, 86) | 62 (50, 103) | ||
| n_control | 66 (48, 106) | 68 (43, 117) | ||
| post_p | 0.14 (0.04, 0.25) | 0.12 (0.03, 0.27) | ||
| order | 2 (1, 4) | 2 (1, 4) | ||
| TEfus+ | count | 176 | 3 | 107 |
| time_stop | 28 (18, 53) | 22 (19, 44) | 25 (18, 38) | |
| n_trt | 75 (51, 131) | 65 (59, 88) | 65 (51, 116) | |
| n_control | 86 (50, 168) | 58 (52, 128) | 73 (48, 130) | |
| post_p | 0.09 (0.02, 0.23) | 0.08 (0.07, 0.14) | 0.1 (0.01, 0.24) | |
| order | 2 (1, 4) | 3 (2.2, 5.4) | 2 (1, 4) |
| signature | treatment | var | — | –+ | -+- | -++ | +– | +-+ | ++- | +++ |
|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 |
| time | 13 (9, 25) | 13 (9, 25) | 13 (9, 25) | 13 (9, 25) | 13 (9, 25) | 13 (9, 25) | 13 (9, 25) | 13 (9, 25) | ||
| n | 30 (18, 70) | 10 (6, 18) | 17 (14, 33) | 14 (9, 20) | 8 (4, 18) | 8 (4, 13) | 6 (2, 12) | 5 (3, 11) | ||
| post_p | 0.79 (0.65, 0.94) | 0.63 (0.56, 0.76) | 0.74 (0.64, 0.85) | 0.6 (0.56, 0.81) | 0.64 (0.58, 0.72) | 0.62 (0.57, 0.76) | 0.67 (0.56, 0.77) | 0.61 (0.55, 0.67) | ||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.004 (0, 0.008) | 0 (0, 0.004) | 0 (0, 0.019) | 0 (0, 0.017) | 0 (0, 0.011) | 0 (0, 0.012) | 0 (0, 0.015) | 0 (0, 0.008) | ||
| Taxel_therapies | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | |
| time | 22 (11, 30) | 22 (11, 30) | 22 (11, 30) | 22 (11, 30) | 22 (11, 30) | 22 (11, 30) | 22 (11, 30) | 22 (11, 30) | ||
| n | 44 (25, 72) | 12 (5, 25) | 30 (10, 41) | 17 (8, 29) | 10 (6, 26) | 12 (10, 21) | 8 (4, 13) | 6 (5, 15) | ||
| post_p | 0.62 (0.57, 0.77) | 0.64 (0.59, 0.76) | 0.64 (0.59, 0.8) | 0.89 (0.64, 0.99) | 0.66 (0.57, 0.75) | 0.65 (0.58, 0.88) | 0.68 (0.56, 0.72) | 0.66 (0.56, 0.81) | ||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.013 (0.003, 0.021) | 0.002 (0, 0.007) | 0.014 (0, 0.021) | 0.003 (0, 0.012) | 0.008 (0, 0.014) | 0 (0, 0.006) | 0.01 (0, 0.016) | 0 (0, 0.009) | ||
| Niraparib | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |
| time | 13 (11, 17) | 13 (11, 17) | 13 (11, 17) | 13 (11, 17) | 13 (11, 17) | 13 (11, 17) | 13 (11, 17) | 13 (11, 17) | ||
| n | 32 (22, 34) | 8 (5, 12) | 20 (11, 26) | 14 (10, 20) | 7 (7, 9) | 8 (7, 8) | 7 (6, 13) | 5 (4, 9) | ||
| post_p | 0.79 (0.78, 0.8) | 0.56 (0.55, 0.6) | 0.69 (0.63, 0.71) | 0.58 (0.57, 0.59) | 0.61 (0.6, 0.74) | 0.58 (0.58, 0.74) | 0.71 (0.64, 0.71) | 0.61 (0.57, 0.7) | ||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||
| rate | 0 (0, 0.008) | 0 (0, 0.01) | 0 (0, 0.009) | 0 (0, 0.009) | 0 (0, 0) | 0 (0, 0.008) | 0 (0, 0) | 0 (0, 0) | ||
| TP53- | Hormone_therapies | count | 204 | 204 | 204 | 204 | ||||
| time | 38 (17, 55) | 38 (17, 55) | 38 (17, 55) | 38 (17, 55) | ||||||
| n | 89 (37, 137) | 24 (10, 46) | 22 (9, 38) | 22 (9, 43) | ||||||
| post_p | 0.96 (0.78, 1) | 0.76 (0.7, 0.92) | 0.78 (0.7, 0.95) | 0.74 (0.64, 0.89) | ||||||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.009 (0.005, 0.013) | 0.007 (0, 0.012) | 0.008 (0, 0.013) | 0.006 (0, 0.011) | ||||||
| Taxel_therapies | count | 4 | 4 | 4 | 4 | |||||
| time | 25 (13, 42) | 25 (13, 42) | 25 (13, 42) | 25 (13, 42) | ||||||
| n | 60 (34, 90) | 13 (8, 24) | 16 (6, 31) | 16 (12, 28) | ||||||
| post_p | 0.76 (0.72, 0.79) | 0.73 (0.66, 0.8) | 0.77 (0.65, 0.84) | 0.78 (0.72, 0.82) | ||||||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.014 (0.004, 0.019) | 0.004 (0, 0.01) | 0.003 (0, 0.012) | 0.002 (0, 0.006) | ||||||
| Niraparib | count | 3 | 3 | 3 | 3 | |||||
| time | 17 (15, 22) | 17 (15, 22) | 17 (15, 22) | 17 (15, 22) | ||||||
| n | 37 (34, 60) | 9 (8, 13) | 11 (11, 15) | 7 (6, 17) | ||||||
| post_p | 0.86 (0.75, 0.94) | 0.82 (0.7, 0.83) | 0.8 (0.72, 0.89) | 0.62 (0.61, 0.78) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.004 (0.001, 0.011) | 0 (0, 0) | 0.01 (0.002, 0.01) | 0 (0, 0) | ||||||
| TP53+ | Taxel_therapies | count | 54 | 54 | 54 | 54 | ||||
| time | 32 (18, 52) | 32 (18, 52) | 32 (18, 52) | 32 (18, 52) | ||||||
| n | 43 (23, 81) | 30 (16, 65) | 12 (5, 27) | 13 (7, 26) | ||||||
| post_p | 0.76 (0.71, 0.89) | 0.85 (0.74, 0.99) | 0.73 (0.64, 0.82) | 0.76 (0.66, 0.93) | ||||||
| r_prob | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.019 (0.01, 0.025) | 0.007 (0, 0.013) | 0.013 (0, 0.021) | 0.006 (0, 0.011) | ||||||
| Niraparib | count | 17 | 17 | 17 | 17 | |||||
| time | 23 (15, 46) | 23 (15, 46) | 23 (15, 46) | 23 (15, 46) | ||||||
| n | 28 (21, 72) | 25 (16, 44) | 11 (6, 26) | 10 (8, 16) | ||||||
| post_p | 0.79 (0.73, 0.86) | 0.76 (0.72, 0.9) | 0.73 (0.64, 0.97) | 0.74 (0.64, 0.82) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.012 (0.006, 0.022) | 0.009 (0.005, 0.018) | 0 (0, 0.009) | 0 (0, 0.01) | ||||||
| DRD+ | Hormone_therapies | count | 9 | 9 | 9 | 9 | ||||
| time | 49 (26, 59) | 49 (26, 59) | 49 (26, 59) | 49 (26, 59) | ||||||
| n | 25 (16, 50) | 20 (11, 48) | 13 (8, 27) | 9 (4, 23) | ||||||
| post_p | 0.79 (0.72, 0.95) | 0.77 (0.72, 0.86) | 0.73 (0.69, 0.85) | 0.71 (0.65, 0.81) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.01 (0.002, 0.014) | 0.008 (0, 0.012) | 0.023 (0.01, 0.025) | 0.016 (0.009, 0.019) | ||||||
| Taxel_therapies | count | 4 | 4 | 4 | 4 | |||||
| time | 46 (30, 56) | 46 (30, 56) | 46 (30, 56) | 46 (30, 56) | ||||||
| n | 20 (11, 30) | 22 (14, 39) | 18 (9, 29) | 14 (12, 29) | ||||||
| post_p | 0.8 (0.66, 0.88) | 0.75 (0.73, 0.88) | 0.82 (0.75, 0.86) | 0.81 (0.72, 0.93) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.017 (0.005, 0.02) | 0.008 (0.005, 0.008) | 0.015 (0.004, 0.018) | 0.006 (0.001, 0.009) | ||||||
| Niraparib | count | 302 | 302 | 302 | 302 | |||||
| time | 41 (26, 56) | 41 (26, 56) | 41 (26, 56) | 41 (26, 56) | ||||||
| n | 24 (11, 41) | 22 (10, 42) | 20 (10, 31) | 19 (9, 33) | ||||||
| post_p | 0.83 (0.71, 0.97) | 0.75 (0.7, 0.9) | 0.89 (0.72, 0.99) | 0.8 (0.71, 0.96) | ||||||
| r_prob | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.008 (0.002, 0.013) | 0.007 (0, 0.011) | 0.008 (0, 0.015) | 0.007 (0, 0.013) | ||||||
| TEfus+ | Hormone_therapies | count | 1 | 1 | 1 | 1 | ||||
| time | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | 21 (21, 21) | ||||||
| n | 18 (18, 18) | 22 (22, 22) | 5 (5, 5) | 10 (10, 10) | ||||||
| post_p | 0.79 (0.79, 0.79) | 0.85 (0.85, 0.85) | 0.6 (0.6, 0.6) | 0.62 (0.62, 0.62) | ||||||
| r_prob | 0.19 (0.19, 0.19) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0 (0, 0) | 0.007 (0.007, 0.007) | 0 (0, 0) | 0.008 (0.008, 0.008) | ||||||
| Taxel_therapies | count | 242 | 242 | 242 | 242 | |||||
| time | 37 (24, 55) | 37 (24, 55) | 37 (24, 55) | 37 (24, 55) | ||||||
| n | 24 (11, 45) | 42 (22, 73) | 22 (9, 41) | 19 (9, 35) | ||||||
| post_p | 0.78 (0.71, 0.93) | 0.91 (0.74, 1) | 0.74 (0.67, 0.9) | 0.79 (0.7, 0.96) | ||||||
| r_prob | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.007 (0, 0.012) | 0.009 (0.004, 0.014) | 0.006 (0, 0.011) | 0.007 (0, 0.013) |
| signature | treatment | var | — | –+ | -+- | -++ | +– | +-+ | ++- | +++ |
|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| time | 18 (11, 29) | 18 (11, 29) | 18 (11, 29) | 18 (11, 29) | 18 (11, 29) | 18 (11, 29) | 18 (11, 29) | 18 (11, 29) | ||
| n | 34 (23, 61) | 9 (7, 14) | 27 (10, 39) | 21 (10, 24) | 8 (6, 14) | 7 (6, 14) | 10 (6, 11) | 8 (5, 11) | ||
| post_p | 0.32 (0.25, 0.48) | 0.39 (0.21, 0.47) | 0.31 (0.26, 0.41) | 0.22 (0.16, 0.38) | 0.44 (0.3, 0.47) | 0.36 (0.31, 0.46) | 0.39 (0.29, 0.45) | 0.37 (0.24, 0.41) | ||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.016 (0.011, 0.035) | 0.021 (0.014, 0.03) | 0.032 (0.023, 0.034) | 0.03 (0.02, 0.047) | 0.012 (0, 0.022) | 0.013 (0.008, 0.021) | 0.025 (0.007, 0.028) | 0.013 (0.005, 0.025) | ||
| Taxel_therapies | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |
| time | 13 (9, 35) | 13 (9, 35) | 13 (9, 35) | 13 (9, 35) | 13 (9, 35) | 13 (9, 35) | 13 (9, 35) | 13 (9, 35) | ||
| n | 29 (19, 33) | 7 (2, 10) | 17 (14, 49) | 11 (9, 34) | 9 (7, 12) | 7 (5, 9) | 4 (3, 13) | 8 (3, 20) | ||
| post_p | 0.22 (0.06, 0.35) | 0.44 (0.36, 0.47) | 0.42 (0.28, 0.43) | 0.33 (0.23, 0.46) | 0.27 (0.25, 0.45) | 0.28 (0.26, 0.43) | 0.43 (0.28, 0.48) | 0.4 (0.37, 0.45) | ||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.021 (0.012, 0.032) | 0.015 (0, 0.021) | 0.022 (0.019, 0.031) | 0.017 (0.005, 0.023) | 0.028 (0.01, 0.044) | 0.015 (0, 0.028) | 0 (0, 0.035) | 0 (0, 0.019) | ||
| Niraparib | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | |
| time | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | 16 (12, 18) | ||
| n | 37 (21, 37) | 11 (7, 13) | 24 (20, 27) | 14 (9, 20) | 9 (6, 11) | 12 (6, 14) | 7 (2, 9) | 6 (5, 9) | ||
| post_p | 0.42 (0.2, 0.5) | 0.17 (0.06, 0.3) | 0.26 (0.24, 0.27) | 0.24 (0.11, 0.4) | 0.46 (0.41, 0.5) | 0.44 (0.3, 0.49) | 0.36 (0.31, 0.48) | 0.38 (0.17, 0.48) | ||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||
| rate | 0.022 (0.017, 0.036) | 0.039 (0.02, 0.065) | 0.029 (0.025, 0.032) | 0.032 (0.014, 0.041) | 0.011 (0, 0.022) | 0.018 (0.011, 0.065) | 0.022 (0.004, 0.059) | 0.019 (0.007, 0.046) | ||
| TP53- | Hormone_therapies | count | 13 | 13 | 13 | 13 | ||||
| time | 15 (11, 29) | 15 (11, 29) | 15 (11, 29) | 15 (11, 29) | ||||||
| n | 34 (29, 61) | 9 (6, 18) | 10 (6, 15) | 7 (5, 11) | ||||||
| post_p | 0.42 (0.29, 0.48) | 0.32 (0.23, 0.4) | 0.38 (0.21, 0.46) | 0.42 (0.32, 0.48) | ||||||
| r_prob | 0.37 (0.37, 0.37) | 0.19 (0.19, 0.19) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.016 (0.011, 0.021) | 0.017 (0.012, 0.03) | 0.019 (0.013, 0.03) | 0.016 (0, 0.022) | ||||||
| Taxel_therapies | count | 158 | 158 | 158 | 158 | |||||
| time | 22 (13, 40) | 22 (13, 40) | 22 (13, 40) | 22 (13, 40) | ||||||
| n | 52 (30, 96) | 15 (9, 32) | 13 (7, 28) | 13 (7, 30) | ||||||
| post_p | 0.19 (0.02, 0.44) | 0.42 (0.27, 0.49) | 0.26 (0.07, 0.43) | 0.4 (0.24, 0.49) | ||||||
| r_prob | 0.25 (0.25, 0.25) | 0.38 (0.38, 0.38) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.022 (0.015, 0.031) | 0.013 (0.007, 0.022) | 0.025 (0.014, 0.051) | 0.012 (0, 0.026) | ||||||
| Niraparib | count | 124 | 124 | 124 | 124 | |||||
| time | 18 (13, 37) | 18 (13, 37) | 18 (13, 37) | 18 (13, 37) | ||||||
| n | 44 (27, 82) | 13 (7, 26) | 12 (6, 26) | 12 (7, 22) | ||||||
| post_p | 0.21 (0.04, 0.42) | 0.26 (0.04, 0.42) | 0.42 (0.31, 0.49) | 0.41 (0.23, 0.49) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.023 (0.015, 0.031) | 0.025 (0.012, 0.05) | 0.014 (0.007, 0.029) | 0.013 (0, 0.027) | ||||||
| TP53+ | Hormone_therapies | count | 362 | 362 | 362 | 362 | ||||
| time | 25 (16, 46) | 25 (16, 46) | 25 (16, 46) | 25 (16, 46) | ||||||
| n | 36 (22, 70) | 25 (15, 57) | 11 (6, 23) | 11 (6, 24) | ||||||
| post_p | 0.35 (0.13, 0.48) | 0.24 (0.05, 0.45) | 0.37 (0.14, 0.48) | 0.31 (0.07, 0.47) | ||||||
| r_prob | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.026 (0.018, 0.034) | 0.025 (0.016, 0.036) | 0.026 (0.016, 0.045) | 0.024 (0.012, 0.044) | ||||||
| Taxel_therapies | count | 28 | 28 | 28 | 28 | |||||
| time | 18 (15, 33) | 18 (15, 33) | 18 (15, 33) | 18 (15, 33) | ||||||
| n | 28 (21, 49) | 19 (14, 36) | 8 (6, 18) | 9 (4, 20) | ||||||
| post_p | 0.34 (0.17, 0.44) | 0.43 (0.28, 0.48) | 0.28 (0.18, 0.46) | 0.41 (0.27, 0.49) | ||||||
| r_prob | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.024 (0.017, 0.038) | 0.016 (0.011, 0.021) | 0.029 (0.019, 0.052) | 0.017 (0.01, 0.035) | ||||||
| Niraparib | count | 35 | 35 | 35 | 35 | |||||
| time | 19 (14, 30) | 19 (14, 30) | 19 (14, 30) | 19 (14, 30) | ||||||
| n | 32 (23, 44) | 23 (15, 33) | 9 (5, 14) | 8 (5, 15) | ||||||
| post_p | 0.28 (0.09, 0.42) | 0.3 (0.08, 0.47) | 0.43 (0.33, 0.48) | 0.4 (0.22, 0.48) | ||||||
| r_prob | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.027 (0.019, 0.035) | 0.023 (0.015, 0.035) | 0.017 (0.01, 0.033) | 0.016 (0, 0.042) | ||||||
| DRD+ | Hormone_therapies | count | 68 | 68 | 68 | 68 | ||||
| time | 28 (23, 44) | 28 (23, 44) | 28 (23, 44) | 28 (23, 44) | ||||||
| n | 18 (12, 32) | 19 (11, 30) | 11 (7, 18) | 10 (6, 20) | ||||||
| post_p | 0.39 (0.21, 0.48) | 0.37 (0.16, 0.48) | 0.3 (0.09, 0.46) | 0.24 (0.07, 0.41) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.017 (0.01, 0.027) | 0.012 (0.006, 0.019) | 0.029 (0.017, 0.053) | 0.026 (0.016, 0.045) | ||||||
| Taxel_therapies | count | 64 | 64 | 64 | 64 | |||||
| time | 30 (22, 46) | 30 (22, 46) | 30 (22, 46) | 30 (22, 46) | ||||||
| n | 16 (9, 30) | 16 (7, 33) | 16 (9, 26) | 15 (8, 23) | ||||||
| post_p | 0.22 (0.05, 0.4) | 0.36 (0.22, 0.48) | 0.29 (0.13, 0.47) | 0.43 (0.33, 0.49) | ||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.025 (0.015, 0.039) | 0.014 (0.008, 0.024) | 0.027 (0.019, 0.037) | 0.015 (0.01, 0.023) | ||||||
| TEfus+ | Hormone_therapies | count | 176 | 176 | 176 | 176 | ||||
| time | 28 (18, 53) | 28 (18, 53) | 28 (18, 53) | 28 (18, 53) | ||||||
| n | 19 (11, 38) | 25 (15, 49) | 17 (10, 34) | 11 (6, 24) | ||||||
| post_p | 0.41 (0.26, 0.49) | 0.2 (0.03, 0.45) | 0.38 (0.21, 0.49) | 0.24 (0.04, 0.45) | ||||||
| r_prob | 0.19 (0.19, 0.19) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.014 (0.009, 0.022) | 0.025 (0.018, 0.036) | 0.012 (0.007, 0.02) | 0.026 (0.015, 0.047) | ||||||
| Taxel_therapies | count | 3 | 3 | 3 | 3 | |||||
| time | 22 (19, 44) | 22 (19, 44) | 22 (19, 44) | 22 (19, 44) | ||||||
| n | 16 (13, 18) | 26 (20, 44) | 10 (7, 12) | 14 (7, 25) | ||||||
| post_p | 0.4 (0.31, 0.47) | 0.36 (0.26, 0.38) | 0.44 (0.29, 0.48) | 0.38 (0.28, 0.4) | ||||||
| r_prob | 0.38 (0.38, 0.38) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | ||||||
| rate | 0.015 (0.009, 0.016) | 0.017 (0.016, 0.02) | 0.009 (0.007, 0.026) | 0.015 (0.011, 0.042) | ||||||
| Niraparib | count | 107 | 107 | 107 | 107 | |||||
| time | 25 (18, 38) | 25 (18, 38) | 25 (18, 38) | 25 (18, 38) | ||||||
| n | 17 (10, 26) | 25 (18, 48) | 14 (8, 26) | 11 (7, 21) | ||||||
| post_p | 0.21 (0.04, 0.45) | 0.26 (0.06, 0.47) | 0.38 (0.2, 0.49) | 0.42 (0.24, 0.49) | ||||||
| r_prob | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | ||||||
| rate | 0.024 (0.012, 0.039) | 0.024 (0.017, 0.034) | 0.014 (0.008, 0.022) | 0.017 (0.008, 0.033) |